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TYMS

Anti-TYMS ProductsBackground
Anti-TYMS Products
- PE-B*51:01/Human TYMS (DAHIYLNHI) MHC Tetramer (MHC-LC1933)
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- Class: Class I
- Antigen: TYMS
- Antigen Species: Human
- Peptide: DAHIYLNHI
- Conjugate: PE
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- Class: Class I
- Antigen: Thymidylate synthase
- Antigen Species: Human
- Peptide: ALLTYMIAHI
- Conjugate: Unlabeled, Biotin, R-PE, APC
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For Research Use Only. Not For Clinical Use.
Background
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Spermatocytes, Extravillous trophoblasts, Plasma cells, Cytotrophoblasts)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Homodimer.
Molecular function
Methyltransferase, Transferase
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