A*02:01/Human Thymidylate synthase (ALLTYMIAHI) MHC Pentamer
CAT#: MHC-YF746
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Thymidylate synthase-derived peptide of ALLTYMIAHI sequence covering 231-240 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
Gene Expression
Normal Tissue
Figure 1 Tonsil
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74922/168838_A_5_8_val_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74922/168838_A_7_8.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74922/168838_A_5_6.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74922/168838_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000176890-TYMS
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Thymidylate synthase
- Antigen Species
- Human
- Peptide
- ALLTYMIAHI
- Range
- 231-240
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
- Alternative Names
- Thymidylate Synthetase; EC 2.1.1.45; TSase; TS; Thymidylate Synthase; HST422; TMS;
- Gene ID
- 7298
- UniProt ID
- P04818
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TYMS"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1404z | Mouse Anti-TYMS Recombinant Antibody (clone 4H6) | WB, ELISA, IHC | Mouse IgG1 |
| MOB-0341MZ | Recombinant Mouse Anti-Human Thymidylate Synthase Antibody (clone US107) | IHC | Mouse antibody |
| MRO-1493-CN | Rabbit Anti-TYMS Recombinant Antibody (clone JM33-20) | WB, IHC, IP, FC | Rabbit IgG |
| ZG-0615U | Rabbit Anti-TYMS Recombinant Antibody (clone 2B2) | ELISA, WB | Rabbit IgG |
| VS3-FY1901 | Rabbit Anti-TYMS Recombinant Antibody (clone R08-2F2) | WB, IHC-Fr, IHC-P, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3733 | Rabbit Anti-TYMS Recombinant Antibody (clone DS3733AB) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1933 | PE-B*51:01/Human TYMS (DAHIYLNHI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC961 | AbPlus™ Anti-TYMS Magnetic Beads (VS-0724-YC961) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2405 | Anti-TYMS Immunohistochemistry Kit | IHC | |
| VS-0525-XY7663 | Anti-Mouse TYMS Immunohistochemistry Kit | IHC | |
| VS-0525-XY7662 | Anti-Human TYMS Immunohistochemistry Kit | IHC |
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