TYROBP

AbPlus Recombinant Antibody Products Formats

Anti-TYROBP Recombinant Antibody Products

Mouse Anti-TYROBP Recombinant Antibody (clone 21D10) (MOB-2427z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IP
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Rabbit Anti-TYROBP Recombinant Antibody (clone JG38-70) (MRO-0456-CN)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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CytoStream™ Rabbit Anti-TYROBP Recombinant Antibody (VS13-YC1195) (VS13-YC1195)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF, FC
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Rabbit Anti-TYROBP Recombinant Antibody (clone DS3736AB) (MOR-3736)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC
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For Research Use Only. Not For Clinical Use.

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Protein class

Disease related genes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Hofbauer cells, Kupffer cells, monocytes, Macrophages, Langerhans cells, NK-cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Group enriched (HMC-1, THP-1)

Interaction

Homodimer; disulfide-linked (PubMed:20890284). Homotrimer; disulfide-linked (PubMed:25981043). Homotetramer; disulfide-linked (PubMed:25981043). Homotrimers and homotetramers form when low levels of partner receptors are available and are competitive with assembly with interacting receptors (PubMed:25981043). They may represent alternative oligomerization states or may be intermediates in the receptor assembly process (PubMed:25981043). Binding of a metal cation aids in homooligomerization through coordination of the metal ion by the subunits of the oligomer (PubMed:25981043). Interacts with TREM1 (PubMed:10799849). Interacts with TREM2 (PubMed:11602640, PubMed:25957402). Interacts with SIRPB1 (PubMed:10604985). Interacts with CLECSF5 (PubMed:10449773). Interacts with SIGLEC14 (PubMed:17012248). Interacts with CD300LB and CD300E (PubMed:15557162, PubMed:16920917, PubMed:17928527). Interacts with CD300C2 (By similarity). Interacts (via ITAM domain) with SYK (via SH2 domains); activates SYK mediating neutrophil and macrophage integrin-mediated activation (By similarity). Interacts with KLRC2, KIR2DS3 and KIR2DS5 (PubMed:18624290, PubMed:20890284). Interacts with CD300H (PubMed:26221034). Interacts with KIR2DS1 (PubMed:23715743). Interacts with KLRD1 (PubMed:9655483, PubMed:15940674).

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