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UBASH3B
Loading...Anti-UBASH3B Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, ELISA, ICC, IF, IHC
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- Anti-UBASH3B Immunohistochemistry Kit (VS-0525-XY7686)
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- Species Reactivity: Human
- Target: UBASH3B
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Extravillous trophoblasts, Langerhans cells, Syncytiotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced
Interaction
Homodimer. Interacts with JAK2 (in vitro) (By similarity). Interacts with CBL (PubMed:15159412). Part of a complex containing CBL and activated EGFR (PubMed:15159412). Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).
Molecular function
Hydrolase, Protein phosphatase
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