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UGT1A6
Anti-UGT1A6 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids, Squamous epithelial cells, Gastric mucus-secreting cells, Basal squamous epithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (OE19)
Interaction
Isoform 1 interacts with isoform 3/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 3. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
Molecular function
Glycosyltransferase, Transferase
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