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ULBP1

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Alveolar cells type 1, Breast myoepithelial cells, Squamous epithelial cells, Respiratory ciliated cells, Alveolar cells type 2)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (fHDF/TERT166, HAP1, HDLM-2, HHSteC, JURKAT)

Interaction

Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710). (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP1 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.

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