+ Filter
Loading...
ULBP1
Anti-ULBP1 Recombinant Antibody Products
- Mouse Anti-ULBP1 Recombinant Antibody (clone CBL195) (NEUT-2241CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2
- Application: FC, Neut
Compare
- Mouse Anti-ULBP1 Recombinant Antibody (clone CBL342) (NEUT-2242CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Block, CyTOF, FC
Compare
More Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Breast myoepithelial cells, Squamous epithelial cells, Respiratory ciliated cells, Alveolar cells type 2)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (fHDF/TERT166, HAP1, HDLM-2, HHSteC, JURKAT)
Interaction
Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710). (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP1 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
More Types Infomation