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For Research Use Only. Not For Clinical Use.


Background

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1.
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Granulosa cells, Endometrial stromal cells, monocytes, Macrophages, Kupffer cells)

Immune cell specificity

Group enriched (classical monocyte, myeloid DC)

Cell line specificity

Cell line enhanced (AF22, HSkMC, hTERT-RPE1, RPTEC TERT1)

Interaction

Interacts with FBLN1.

More Types Infomation
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