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VHSV M1

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For Research Use Only. Not For Clinical Use.


Background

Viral Hemorrhagic Septicemia virus (VHSV) is a pathogenic fish rhabdovirus found in discrete locales throughout the northern hemisphere. VHSV infection of fish cells leads to upregulation of the host's virus detection response, but the virus quickly suppresses interferon (IFN) production and antiviral genes expression. Data have demonstrated that VHSV M plays an important role in mediating both virus-induced cell toxicity and viral replication and its roles in these two processes can be separated to design effective attenuated viruses for vaccine candidates.
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