WISP2

WISP2 is a member of the connective tissue growth factor/hypercysteine 61/connective tissue growth factor (nephmblastoma overexpressed gene, CCN) family. WISP2 is mainly localized to the cytoplasm, and a few of the nuclear coloring CCN families act as a mesenchymal protein, which can cross-link with many kinds of signaling molecules, including extracellular matrix proteins, heparin sulfate proteoglycans, and multiple receptor proteins (low Density lipoprotein receptor-related proteins, integrin, Notch protein, etc., calcium-binding proteins and ion channel proteins, etc., participate in intracellular and extracellular signaling pathways, regulate cell division, cell adhesion, cell migration, and induce cell withering Death and cartilage ossification play an important role. As a member of the CCN family, WISP2 has similar capabilities. The study found that the biological functions of WISP2 are different in different tumors, and WISP2 regulates the development of tumors in a positive or negative direction.