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ZP1
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For Research Use Only. Not For Clinical Use.
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility.
Protein class
Disease related genes, Human disease related genes
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (Late spermatids, Early spermatids)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Group enriched (RPMI-8226, SK-BR-3)
Interaction
Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity). Interacts with ZP3 (PubMed:28886344).
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