algD

GDP-mannose 6-dehydrogenase is an enzyme involved in the biosynthesis of GDP-fucose, a crucial sugar nucleotide precursor for many glycoconjugates. It catalyzes the NAD(P)⁺-dependent oxidation of GDP-mannose to GDP-mannose 6-phosphate, which is then further converted. This enzyme plays a vital role in regulating the availability of fucose residues for glycosylation processes essential for cell-cell recognition and signaling.