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hisG

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For Research Use Only. Not For Clinical Use.


Background

ATP phosphoribosyltransferase (ATP PRT) is the first enzyme in the histidine biosynthetic pathway. It catalyzes the condensation of ATP and phosphoribosyl pyrophosphate (PRPP) to form N'-5'-phosphoribosyl-ATP. This enzyme is a major regulatory point for histidine synthesis and is often subject to feedback inhibition.
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