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kdsA

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For Research Use Only. Not For Clinical Use.


kdsA, or 2-dehydro-3-deoxyphosphooctonate aldolase (KDO8P synthase), is the first committed enzyme in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO). KDO is an essential component of the lipopolysaccharide (LPS) of Gram-negative bacteria. KdsA is a crucial target for developing new antibiotics targeting bacterial cell envelopes.
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