proTGF i-GARP complex

Regulatory T cells, or Tregs, are a subset of CD4+ T lymphocytes specialized in the inhibition of immune responses. Insufficient Treg function results in autoimmune pathology, while excessive Treg function may inhibit anti-tumor immune responses in cancer patients. The exact mechanisms by which Tregs inhibit immune responses are not fully understood. Due to their immunosuppressive functions, Tregs represent potential inhibitors of spontaneous or vaccine-induced anti -tumor immune responses. In murine models, the depletion of Tregs can improve immune responses against experimental tumors. Thus, targeting Tregs in humans could improve the efficacy of immunotherapy against cancer.