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serca, or P-type Ca²⁺-transporting ATPase (Sarco/endoplasmic reticulum Ca²⁺-ATPase), is a membrane protein that actively pumps calcium ions from the cytoplasm into the sarcoplasmic or endoplasmic reticulum lumen, using energy from ATP hydrolysis. SERCA plays a critical role in regulating intracellular calcium levels, essential for muscle contraction, neuronal signaling, and protein folding.
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