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TP53BP1

Anti-TP53BP1 Products
- Rabbit Anti-TP53BP1 Recombinant Antibody (clone JA66-11) (MRO-0009-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
- Mouse Anti-TP53BP1 Recombinant Antibody (clone 8D5) (VS3-XY1543)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, IP-MS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC-P, FC
- Mouse Anti-TP53BP1 Recombinant Antibody (clone 6B3E10) (VS7-0425-WR1037)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, FC
- Anti-TP53BP1 Immunohistochemistry Kit (VS-0525-XY7440)
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- Species Reactivity: Human
- Target: TP53BP1
- Application: IHC
- Anti-Mouse TP53BP1 Immunohistochemistry Kit (VS-0525-XY7441)
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- Species Reactivity: Human, Mouse, Rat, Monkey
- Target: TP53BP1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.