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    APC-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (CAT#: MHC-LC1590)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of CACNA1D-derived peptide of SRRWRRWNR covering 513-521 and B*27:05 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
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    Form Requested *:
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    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line CACO-2
    Figure 1 IF staining of human cell line CACO-2
    (Immunofluorescent staining of human cell line CACO-2 shows localization to nuclear membrane.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/1525_G2_6_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_B_9_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_4.jpg
    Figure 5 Pancreas
    Figure 5 Pancreas
    (Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_3_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_4_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/20215/47850_A_7_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3)
    Figure 9 RNA cell line category: Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157388-CACNA1D

    Specifications

    • Allele
    • B*27:05
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • CACNA1D
    • Antigen Species
    • Human
    • Peptide
    • SRRWRRWNR
    • Range
    • 513-521
    • Conjugate
    • APC
    • Application
    • FCM

    Target

    • Antigen Introduction
    • Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
    • Alternative Names
    • CACNA1D; calcium voltage-gated channel subunit alpha1 D; CACH3; CACN4; PASNA; SANDD; Cav1.3; CCHL1A2; CACNL1A2

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    MHC-LC1589 PE-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer FCM
    MHC-LC1591 BV421-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer FCM

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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