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CACNA1D

Anti-CACNA1D Products

PE-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (MHC-LC1589)
- Class: Class I
- Antigen: CACNA1D
- Antigen Species: Human
- Peptide: SRRWRRWNR
- Conjugate: PE
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APC-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (MHC-LC1590)
- Class: Class I
- Antigen: CACNA1D
- Antigen Species: Human
- Peptide: SRRWRRWNR
- Conjugate: APC
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BV421-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (MHC-LC1591)
- Class: Class I
- Antigen: CACNA1D
- Antigen Species: Human
- Peptide: SRRWRRWNR
- Conjugate: BV421
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Anti-CACNA1D Immunohistochemistry Kit (VS-0525-XY916)
- Species Reactivity: Human
- Target: CACNA1D
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

Protein class

Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Transporters, Voltage-gated ion channels

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Microglial cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3)

Interaction

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Channel activity is further modulated, depending on the presence of specific delta subunit isoforms. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner (By similarity). Interacts with RIMBP2 (By similarity).

Molecular function

Calcium channel, Ion channel, Voltage-gated channel

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