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Anti-Human APN Recombinant Antibody (MT95-4) (CAT#: TAB-0939CLV)

The anti-APN antibody is a fully humanized antibody targeting aminopeptidase N, and the antibody can be used for monoclonal antibody-based anticancer therapy.


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FuncS

Figure 1 Function of a fully humanized monoclonal antibody, MT95-4, in vitro.

Figure 1 Function of a fully humanized monoclonal antibody, MT95-4, in vitro.

Effects of MT95-4 on the aminopeptidase activity of HT1080 cells. The levels of AMC released from Ala-MCA were measured.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 2 Function of a fully humanized monoclonal antibody, MT95-4, in vitro.

Figure 2 Function of a fully humanized monoclonal antibody, MT95-4, in vitro.

Effects of MT95-4 on the invasion of HT1080 cells in a Matrigel invasion assay.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 3 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Figure 3 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Evaluation of the number of lung surface nodules in the tail vein metastasis model following injection of APN-B16 cells. The number of tumor nodules on the lung surface was counted 21 days after injection of APN-B16 cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 4 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Figure 4 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Evaluation of tumor volume in a subcutaneous tumor model using APNB16 cells. The sizes of subcutaneous tumors were measured twice a week for 2 weeks after inoculation of APN-B16 cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 5 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Figure 5 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Evaluation of angiogenesis in subcutaneous tumors derived from APN-B16 cells. The area of CD31-positive vessels was measured.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

IHC

Figure 6 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Figure 6 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using APN-B16 cells.

Immunohistochemical staining for CD31 in a subcutaneous tumor.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 7 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 7 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Evaluation of tumor volumes in a subcutaneous tumor model using H1299 cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 8 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 8 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Evaluation of tumor volumes in a subcutaneous tumor model using PC14 cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 9 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 9 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Evaluation of tumor volumes in a subcutaneous tumor model using A549 cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 10 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 10 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Evaluation of angiogenesis in subcutaneous tumors derived from H1299 (d), PC14 (g) and A549 (j) cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 11 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 11 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Evaluation of angiogenesis in subcutaneous tumors derived from H1299 (d), PC14 (g) and A549 (j) cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

FuncS

Figure 12 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 12 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Evaluation of angiogenesis in subcutaneous tumors derived from H1299 (d), PC14 (g) and A549 (j) cells.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

IHC

Figure 13 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 13 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Immunohistochemical staining for CD31 in a subcutaneous tumor.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

IHC

Figure 14 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 14 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Immunohistochemical staining for CD31 in a subcutaneous tumor.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.

IHC

Figure 15 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Figure 15 Effects of MT95-4 on tumor progression in the tail vein metastasis model and subcutaneous tumor model using human lung cancer cells. Mice were administered MT95-4 or control IgG.

Immunohistochemical staining for CD31 in a subcutaneous tumor.

Akita, S., Hattori, N., Masuda, T., Horimasu, Y., Nakashima, T., Iwamoto, H., ... & Kohno, N. (2015). MT 95‐4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model. Cancer science, 106(7), 921-928.


Specifications

  • Immunogen
  • HT1080 human fibrosarcoma cell
  • Host Species
  • Mouse
  • Type
  • Fully human antibody
  • Specificity
  • Human
  • Clone
  • MT95-4
  • Applications
  • FuncS, IHC
  • Related Disease
  • Cancer

Applications

  • Application Notes
  • The antibody was validated for Functional Assay, Immunohistochemistry. For details, refer to Published Data.

Target

  • Alternative Names
  • ANPEP, APN, CD13, GP150, LAP1, P150, PEPN, alanyl aminopeptidase, membrane

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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