Anti-CCL16 immunotoxin FD441.8 (IgG)-RTA
CAT#: AGTO-G075R
This immunotoxin was achieved by conjugating/fusing the Anti-CCL16 monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CCL16 positive cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Graft-versus-host disease (GVHD).
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000275152-CCL16
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- FD441.8
- Molecule Class
- IgG-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Graft-versus-host disease (GVHD)
Target
- Alternative Names
- CCL16; chemokine (C-C motif) ligand 16; LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16; C-C motif chemokine 16; monotactin-1; chemokine LEC; new CC chemokine 4; liver CC chemokine-1; IL-10-inducible chemokine; liver-expressed chemokine; small-inducible cytokine A16; lymphocyte and monocyte chemoattractant; small inducible cytokine subfamily A (Cys-Cys), member 16; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 6360
- UniProt ID
- O15467
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
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See other products for "Clone FD441.8"
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- Product Name
See other products for "CCL16"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1079CT | Mouse Anti-CCL16 Recombinant Antibody (clone LEC67) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0090MZ | Chicken Anti-CCL16 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-135CQ | Mouse Anti-CCL16 Recombinant Antibody (clone CBL179) | Neut, WB, IHC | Mouse IgG1 |
| NEUT-136CQ | Mouse Anti-CCL16 Recombinant Antibody (clone CBL487) | WB, IHC, CyTOF, ELISA(Cap), ICFC, Neut | Mouse IgG1 |
| NEUT-137CQ | Mouse Anti-CCL16 Recombinant Antibody (clone MM0140-3J10) | WB, Neut, IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0503 | Hi-Affi™ Rabbit Anti-CCL16 Recombinant Antibody (clone DS503AB) | WB | Rabbit IgG |
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