Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD33. Lintuzumab is a humanized monoclonal antibody used in the treatment of cancer.
Figure 1 Reductions in bone marrow blasts were seen at all dose levels.
Percentage change in bone marrow blasts after treatment with sequential cytarabine and 213 Bi-lintuzumab in 26 evaluable patients.
Rosenblat, T. L., McDevitt, M. R., Mulford, D. A., Pandit-Taskar, N., Divgi, C. R., Panageas, K. S., ... & Larson, S. M. (2010). Sequential cytarabine and α-particle immunotherapy with bismuth-213–lintuzumab (HuM195) for acute myeloid leukemia. Clinical Cancer Research, 1078-0432.
Figure 2 Flow cytometry-based cytotoxicity assay for quantification of AMG330-specific lysis of myeloid cells.
The CD33+ cell line U937 was co-incubated for 24 h with MNC from a healthy donor at an E:T ratio of 1:1 (referred to CD3+ T-cell) in the presence of AMG330 or Control Ab constructs. Dot plots are gated on live, single, CD45+ cells and show CD13+ CD14+ monocytes in blue, donor CD3+ T-cells in green and CD56+ CD14+ U937 target cells in orange. The percentage of respective populations in culture at baseline and after 24 h is given in the table.
Aigner, M., Feulner, J., Schaffer, S., Kischel, R., Kufer, P., Schneider, K., ... & Mackensen, A. (2013). T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia, 27(5), 1107.
Figure 3 The effect of pre-stimulation of autologous T-cells on AMG330-mediated redirected lysis of primary autologous AML blasts.
AML samples were co-cultured for 144 h in the presence of 1 ng/ml AMG330 (CD33 BiTE), 1 ng/ml Control BiTE, or no BiTE. CD8+ T-cells were harvested from these cultures and incubated for the indicated time points together with a second MNC sample from the same patient at an E:T ratio of 1:1. A mean of four independent experiments from four different AML patients±s.d. is shown.
Aigner, M., Feulner, J., Schaffer, S., Kischel, R., Kufer, P., Schneider, K., ... & Mackensen, A. (2013). T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia, 27(5), 1107.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Afuco™ Anti-CD33 ADCC Recombinant Antibody (Lintuzumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD33. Lintuzumab is a humanized monoclonal antibody used in the treatment of cancer.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-321-sdAb | Recombinant Anti-human CD33 VHH Single Domain Antibody | WB, IP, ChiP, Neut, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-013 | Humanized Anti-CD33 Recombinant Antibody (clone Gemtuzumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | Humanized (from mouse) IgG4, κ |
TAB-H37 | Anti-Human CD33 Recombinant Antibody (Gemtuzumab Ozogamicin) | ELISA, FC, IP, FuncS, IF, Neut, IHC | IgG |
VS3-WK1523 | Human Anti-CD33 Recombinant Antibody (clone CDP-771) | FC | Humanized IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G008E | Anti-CD33 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G008G | Anti-CD33 immunotoxin (scFv)-Gel | Cytotoxicity assay, Function study | |
AGTO-L050E | anti-CD33 immunotoxin M195 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L050G | anti-CD33 immunotoxin M195 (IgG)-Gel | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-123LC | Anti-Human CD33 Recombinant Antibody | FC | Human antibody |
TAB-146LC | Human Anti-CD33 Recombinant Antibody (TAB-146LC) | ELISA | Human IgG |
TAB-123LC-S(P) | Anti-Human CD33 Recombinant Antibody scFv Fragment | FC | Human antibody |
TAB-123LC-F(E) | Anti-Human CD33 Recombinant Antibody Fab Fragment | FC | Human antibody |
TAB-146LC-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (TAB-146LC-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-136LC-S(P) | Mouse Anti-CD33 Recombinant Antibody; scFv Fragment (TAB-136LC-S(P)) | ELISA, FC | Mouse scFv |
TAB-137LC-S(P) | Mouse Anti-CD33 Recombinant Antibody; scFv Fragment (TAB-137LC-S(P)) | ELISA, FC | Mouse scFv |
TAB-138LC-S(P) | Mouse Anti-CD33 Recombinant Antibody; scFv Fragment (TAB-138LC-S(P)) | ELISA, FC | Mouse scFv |
TAB-139LC-S(P) | Mouse Anti-CD33 Recombinant Antibody; scFv Fragment (TAB-139LC-S(P)) | ELISA, FC | Mouse scFv |
TAB-140LC-S(P) | Mouse Anti-CD33 Recombinant Antibody; scFv Fragment (TAB-140LC-S(P)) | ELISA, FC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-013LC | Recombinant Anti-Human CD33 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-341CQ | Mouse Anti-CD33 Recombinant Antibody (clone WM53) | FC, IHC-Fr, ICC, IP, WB, Block | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0553 | Hi-Affi™ Rabbit Anti-CD33 Recombinant Antibody (clone DS553AB) | WB, ICC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-471CQ | Anti-Human CD33 Recombinant Antibody (Vadastuximab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0045CQ | Human Anti-CD33 Recombinant Antibody (clone huM195) | ELISA, FC, FuncS | Humanized IgG1 |
HPAB-0307-FY | Human Anti-CD33 Recombinant Antibody (clone GO) | WB | Humanized IgG |
HPAB-M0471-YC | Human Anti-CD33 Recombinant Antibody (HPAB-M0471-YC) | FuncS | Humanized IgG |
HPAB-1929LY | Human Anti-CD33 Recombinant Antibody (HPAB-1929LY) | FC | Humanized IgG |
HPAB-1930LY | Human Anti-CD33 Recombinant Antibody (HPAB-1930LY) | FC | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-471CQ | Afuco™ Anti-CD33 ADCC Recombinant Antibody (Vadastuximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-756 | Afuco™ Anti-CD33 ADCC Recombinant Antibody (Lintuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-013 | Afuco™ Anti-CD33 ADCC Recombinant Antibody (Gemtuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1983LY-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1983LY-F(E)) | FC | Humanized Fab |
HPAB-1984LY-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1984LY-F(E)) | FC | Humanized Fab |
HPAB-1985LY-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1985LY-F(E)) | FC | Humanized Fab |
HPAB-1986LY-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1986LY-F(E)) | FC | Humanized Fab |
HPAB-1987LY-F(E) | Human Anti-CD33 Recombinant Antibody; Fab Fragment (HPAB-1987LY-F(E)) | FC | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2049LY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-2049LY-S(P)) | FC, ELISA | Humanized scfv |
HPAB-0374-FY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-0374-FY-S(P)) | FC, ELISA | Human scFv |
HPAB-0375-FY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-0375-FY-S(P)) | ELISA | Humanized scFv |
HPAB-0376-FY-S(P) | Human Anti-CD33 Recombinant Antibody; scFv Fragment (HPAB-0376-FY-S(P)) | ELISA | Human scFv |
HPAB-0532-YJ-S(P) | Human Anti-CD33 Recombinant Antibody (clone ZJL101); scFv Fragment | ELISA, Inhib | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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