This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to scIL12 and IL2. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of scIL12 and IL2. IL12-Ab-IL2 cytokine fusion proteins were effective in harnessing the synergistic activities of the individual cytokines present on the molecule. Thus, the synergistic activities of IL2 and IL12 inhibited tumor growth, which in addition had a potent paracrine effect on tumor cells that were not secreting these cytokines. This Immunocytokines was designed for treating solid tumor.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-106 | Anti-Human EPCAM Recombinant Antibody (Adecatumumab) | FC, IHC, FuncS, Inhib, Cyt | IgG1 |
TAB-356MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (3-171) | FC, ELISA | Human antibody |
TAB-357MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (7-F17) | FC, ELISA | Human antibody |
TAB-358MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (12-C15) | FC, ELISA | Human antibody |
TAB-359MZ-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (16-G5) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-112-F(E) | Anti-Human EpCAM Recombinant Antibody Fab Fragment, 17-1A (Citatuzumab Bogatox) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Fab - G1 - kappa |
TAB-235CL | Human Anti-Human EPCAM Recombinant Antibody (3622W94) | Cyt, FC | Antibody |
TAB-374MZ | Anti-Human EPCAM Recombinant Antibody (h12H8B) | FC, ELISA | Humanized antibody |
TAB-375MZ | Anti-Human EPCAM Recombinant Antibody (h12H8C) | FuncS, Inhib | Humanized antibody |
TAB-376MZ | Anti-Human EPCAM Recombinant Antibody (h2D11B) | Cyt, Inhib | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L013E | anti-EPCAM immunotoxin MOC31 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L013D | anti-EPCAM immunotoxin MOC31 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L013G | anti-EPCAM immunotoxin MOC31 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
AGTO-L013R | anti-EPCAM immunotoxin MOC31 (IgG)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L013O | anti-EPCAM immunotoxin MOC31 (IgG)-Bouganin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0531CL-F(E) | Anti-Human EPCAM Recombinant Antibody Fab Fragment (HE2) | ELISA, Inhib | |
TAB-363MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-363MZ) | ELISA, FuncS | Mouse IgG1, κ |
TAB-364MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-364MZ) | FC | Mouse IgG1 |
TAB-365MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-365MZ) | FC | Mouse IgG1 |
TAB-366MZ | Mouse Anti-EPCAM Recombinant Antibody (TAB-366MZ) | ELISA, FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1163 | Hi-Affi™ Rabbit Anti-EPCAM Recombinant Antibody (clone DS1163AB) | IHC-P, WB, ICC, ICC, IF | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0095YC | Mouse Anti-EPCAM Recombinant Antibody (clone MOC31) | ELISA | Mouse IgG1, κ |
FAMAB-0129CQ | Human Anti-EPCAM Recombinant Antibody (clone 17-1A) | ELISA, IHC, FC | Chimeric (mouse/human) IgG |
FAMAB-0130CQ | Human Anti-EPCAM Recombinant Antibody (clone 323/A3) | ELISA, IHC, FC | Chimeric (mouse/human) IgG |
FAMAB-0131CQ | Mouse Anti-EPCAM Recombinant Antibody (clone MOC-161) | ELISA, IHC, FC | Mouse IgG2a, κ |
HPAB-0163CQ | Human Anti-EPCAM Recombinant Antibody (clone HuMAB UBS-54) | ELISA, FC, FuncS | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-106 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Adecatumumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
AFC-TAB-213 | Afuco™ Anti-EPCAM ADCC Recombinant Antibody (Tucotuzumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS | ADCC enhanced antibody |
AFC-TAB-701 | Afuco™ Anti-EpCAM ADCC Recombinant Antibody (Edrecolomab), ADCC Enhanced | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-2216LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2216LY-F(E)) | ELISA | Human Fab |
HPAB-2217LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2217LY-F(E)) | ELISA | Human Fab |
HPAB-2218LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2218LY-F(E)) | ELISA | Human Fab |
HPAB-2219LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2219LY-F(E)) | ELISA | Human Fab |
HPAB-2220LY-F(E) | Human Anti-EPCAM Recombinant Antibody; Fab Fragment (HPAB-2220LY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0031 | APC-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM | |
MHC-CN0032 | PE-H-2Db/Human Ep-CAM (CLVMKAEM) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0639-YJ-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone ch FU-MK-1); scFv Fragment | ELISA, FC, WB | Mouse scFv |
HPAB-S0025-YC-S(P) | Mouse Anti-EPCAM Recombinant Antibody (clone M79); scFv Fragment | ELISA, FC | Mouse scFv |
HPAB-S0026-YC-S(P) | Human Anti-EPCAM Recombinant Antibody (clone H79); scFv Fragment | ELISA, FC, Cyt | Human scFv |
HPAB-2050-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone K53); scFv Fragment | FC | Human scFv |
HPAB-2051-FY-S(P) | Human Anti-EpCAM Recombinant Antibody (clone 02-237); scFv Fragment | FC | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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