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    Anti-EpCAM Antibody-Cytokine Fusion Protein, IL12-IgG (KS)-IL2

    CAT#: ACFP-SH182

    This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL12 and IL2. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL12 and IL2. Cytokine activity was retained in constructs where one cytokine was fused at the carboxyl terminus of the H chain while the second cytokine was fused to the amino terminus of either the light (L) chain variable region, antigen binding of the antibody-cytokine fusion proteins could be maintained. These IL-12/IL-2 bi-functional fusion proteins were shown to induce extremely high levels of interferon-gamma (IFN-γ), similar to the synergy normally seen with the combined application of the individual cytokines. These bifunctional molecules were shown to have striking anti-tumor activity as either gene therapy or as an antibody cytokine (s) fusion protein, and may provide a useful approach to the treatment of cancer.

    Gene Expression
    ❮
    Figure 1 IF staining of human cell line MCF7 Figure 2 Thyroid gland Figure 3 Colon Figure 4 Kidney Figure 5 RNA cell line category: Cell line enhanced (A-431, CACO-2, CAPAN-2, OE19, RPTEC TERT1)
    ❯

    Specifications

    • Target
    • EpCAM
    • Molecule Class
    • IL12-IgG1-IL2
    • Species Reactivity
    • Human
    • Expression Host
    • CHO
    • Clone
    • KS
    • Related Disease
    • Solid tumor
    • Cytokine 1
    • IL12
    • Cytokines 1 Description
    • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
    • Cytokine 1 Species
    • Mouse
    • Cytokine 2
    • IL2
    • Cytokines 2 Description
    • Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
    • Cytokine 2 Species
    • Mouse
    • Applications
    • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

    Target

    • Alternative Names
    • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)
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    Datasheet

    Datasheet - ACFP-SH182.pdf

    MSDS

    MSDS - ACFP-SH182.pdf

    COA

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