Anti-EpCAM Immunocytokine, scIL12-linker-IgG (KS)-IL2 (ACFP-SH149)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2. It was expressed in CHO and purified with affinity chromatography. This bi-antibody-cytokine fusion protein showed effective antigen binding and cytokine activity. IL12-KS-IL2 exhibits significant antitumor activity, similar to that observed when the combination of KS-(IL2) and KS-(IL12) was used. This immunocytokine was designed for treating solid tumor.
Specifications
- Target
- EpCAM
- Molecule Class
- scIL12-linker-IgG1-IL2
- Species Reactivity
- Human
- Host
- Mouse
- Expression Host
- CHO
- Clone
- KS
- Related Disease
- Solid tumor
- Cytokines 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
- Entrez Gene ID
- 4072
- UniProt ID
- P16422
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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