Anti-EpCAM Immunocytokine, IgG (KS)-scIL12-IL2 (ACFP-SH185)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to scIL12 and IL2. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of scIL12 and IL2. The IL-12/IL-2 bi-functional fusion proteins were shown to induce extremely high levels of interferon-gamma (IFN-γ), similar to the synergy normally seen with the combined application of the individual cytokines. In addition, the bifunctional molecules were shown to have striking anti-tumor activity as either gene therapy or as an antibody cytokine(s) fusion protein, and may provide a useful approach to the treatment of cancer. This Immunocytokines was designed for treating solid tumor.
Specifications
- Target
- EpCAM
- Molecule Class
- IgG1-scIL12-IL2
- Species Reactivity
- Human
- Host
- Mouse
- Expression Host
- CHO
- Clone
- KS
- Related Disease
- Solid tumor
- Cytokines 1
- scIL12
- Cytokines 1 Description
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
- Cytokine 1 Species
- Mouse
- Cytokines 2
- IL2
- Cytokines 2 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 2 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
- Entrez Gene ID
- 4072
- UniProt ID
- P16422
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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