This product is a recombinant mouse anti-Human astrovirus monoclonal antibody (PL-2). PL-2 specifically binds to capsid protein associated with HAstV and can be potentially used in the treatment and diagnosis of human astrovirus infection.
Figure 1 Antibody PL-2 binds with high specificity and affinity to Spike2.
ELISA showing mAb PL-2 binds to Spike2 but not Spike1 or Spike8.
Structure of a Human Astrovirus Capsid - Antibody Complex and Mechanistic Insights into Virus Neutralization
Figure 2 Antibody PL-2 binds with high specificity and affinity to Spike2.
Background-subtracted SPR traces (orange) and curve fit with a 1:1 binding model (black). Sequential injections of increasing concentrations of Fab PL2 were tested with immobilized Spike2.
Structure of a Human Astrovirus Capsid - Antibody Complex and Mechanistic Insights into Virus Neutralization
Figure 3 Intermolecular interactions at the scFv PL-2/Spike2 interface.
ELISA showing binding of mAb PL-2 to Spike2 mutants.
Structure of a Human Astrovirus Capsid - Antibody Complex and Mechanistic Insights into Virus Neutralization
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1182LC-S(P) | Anti-HAtVs CP Recombinant Antibody scFv Fragment (PL-2) | ELISA, WB | Mouse Antibody |
MRO-1182LC-F(E) | Anti-HAtVs CP Recombinant Antibody Fab Fragment (PL-2) | ELISA, WB | Mouse Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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