Anti-HIV-1 gp120 V3 Recombinant Antibody (HGN194) (CAT#: MRO-068LC)
This product is a recombinant human anti-HIV-1 monoclonal antibody. HGN194 specifically binds to gp120 V3 and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
ELISA
Figure 1. ELISA binding of HGN194 isotypes to gp120: detection with goat anti-human Abs.
Watkins, J. D., Sholukh, A. M., Mukhtar, M. M., Siddappa, N. B., Lakhashe, S. K., Kim, M., ... & Villinger, F. (2013). Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS (London, England), 27(9), F13.
Neut
Fifure 2. The V2 region of subtype C viruses modulates access to V3.
The results show that virus susceptibility to neutralization by mAb HGN194 can be transferred by swapping of the V2 regions between sensitive (Du179) and resistant virus (ZM249M).
Manhas, S., Chau, D., Rempel, C., Clark, B. E., Auyeung, K., & Pantophlet, R. (2014). The presence of glutamine at position 315 but not epitope masking predominantly hinders HIV subtype C neutralization by the anti-V3 antibody B4e8. Virology, 462, 98-106.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- HGN194
- Applications
- ELISA, Neut
- Related Disease
- AIDS
Applications
- Application Notes
- The HGN194 antibody has been reported in applications of ELISA, Neut.
It's recommended that the optimal antibody concentration, dilution, incubation time etc. are best to be carefully titrated in specific assays. For details, refer to Published Data.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120 V3 loop; gp120 V3 loop; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
Human Antibody Products
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-477-F(E) | Recombinant Anti-HIV-1 gp120 V3 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| MHH-477-F(E) | Recombinant Human Anti-HIV-1 gp120 V3 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
| PFBL-176 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2424); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBC-067 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody; Fab Fragment (PFBC-067) | ELISA, Neut | Human Fab |
| PFBC-278 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 1334); Fab Fragment | ELISA, Neut | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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