Anti-HIV-1 gp120 V3 Recombinant Antibody (HGN194) (CAT#: MRO-068LC)
This product is a recombinant human anti-HIV-1 monoclonal antibody. HGN194 specifically binds to gp120 V3 and can be potentially used in the treatment of acquired immunodeficiency syndrome (AIDS), a condition in humans characterized by clinical features including wasting syndromes, central nervous system degeneration and profound immunosuppression that results in life-threatening opportunistic infections and malignancies.
Specific Inquiry
ELISA
Figure 1. ELISA binding of HGN194 isotypes to gp120: detection with goat anti-human Abs.
Watkins, J. D., Sholukh, A. M., Mukhtar, M. M., Siddappa, N. B., Lakhashe, S. K., Kim, M., ... & Villinger, F. (2013). Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS (London, England), 27(9), F13.
Neut
Fifure 2. The V2 region of subtype C viruses modulates access to V3.
The results show that virus susceptibility to neutralization by mAb HGN194 can be transferred by swapping of the V2 regions between sensitive (Du179) and resistant virus (ZM249M).
Manhas, S., Chau, D., Rempel, C., Clark, B. E., Auyeung, K., & Pantophlet, R. (2014). The presence of glutamine at position 315 but not epitope masking predominantly hinders HIV subtype C neutralization by the anti-V3 antibody B4e8. Virology, 462, 98-106.
Specifications
- Host Species
- Human
- Type
- Human antibody
- Specificity
- HIV-1
- Clone
- HGN194
- Applications
- ELISA, Neut
- Related Disease
- AIDS
Applications
- Application Notes
- The HGN194 antibody has been reported in applications of ELISA, Neut.
It's recommended that the optimal antibody concentration, dilution, incubation time etc. are best to be carefully titrated in specific assays. For details, refer to Published Data.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120 V3 loop; gp120 V3 loop; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone HGN194"
See other products for "HIV-1 gp120 V3"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-477-S(P) | Recombinant Anti-HIV-1 gp120 V3 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| MHH-477-S(P) | Recombinant Human Anti-HIV-1 gp120 V3 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| PSBL-176 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2424); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBC-067 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody; scFv Fragment (PSBC-067) | ELISA, Neut | Human scFv |
| MRO-3663CQ-S(P) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2.1E (2.1e)); scFv Fragment | ELISA | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-068LC-S(P) | Anti-HIV-1 gp120 V3 Recombinant Antibody scFv Fragment (HGN194) | ELISA | Human antibody |
| MRO-068LC-F(E) | Anti-HIV-1 gp120 V3 Recombinant Antibody Fab Fragment (HGN194) | ELISA | Human antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-3663CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 2.1E (2.1e)); Fab Fragment | ELISA | Human Fab |
| MRO-3664CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 3904); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3665CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 4121); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3666CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 3694); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-3667CQ-F(E) | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 3791); Fab Fragment | ELISA, Neut | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-278 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 1334) | ELISA, Neut | Human IgG |
| PABC-280 | Rabbit Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 10A37) | ELISA, Neut | Rabbit IgG |
| PABC-281 | Rabbit Anti-HIV-1 gp120 V3 Recombinant Antibody (clone 10A3) | ELISA | Rabbit IgG |
| PABC-296 | Human Anti-HIV-1 gp120 V3 Recombinant Antibody (PABC-296) | ELISA, Neut | Human IgG |
| PABC-297 | Monkey Anti-HIV-1 gp120 V3 Recombinant Antibody (PABC-297) | ELISA, FC, SPR, Neut | Monkey IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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