Recombinant Mouse Anti-NV VLP Antibody (5B18) (CAT#: PABL-667)
Recombinant Mouse Antibody (5B18) is capable of binding to NV VLP , expressed in Chinese Hamster Ovary cells (CHO). This antibody was found to bind to numerous GII genotypes but not GI noroviruses.
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Figure 1 NoV VLPs specifically bound and internalized into human small intestinal epithelium.
The results of experiment with the 5B18 mouse monoclonal antibody as primary antibody are depicted in the panels, respectively.
Murakami, K., Kurihara, C., Oka, T., Shimoike, T., Fujii, Y., Takai-Todaka, R., ... & Miura, S. (2013). Norovirus binding to intestinal epithelial cells is independent of histo-blood group antigens. PloS one, 8(6), e66534.
Figure 2 An antibody ELISA was used to determine the binding ability of IgG to GII.10 VLPs
The same VLPs shown in panel A were used in an ELISA to compare the binding ability of 5B18 IgG.
Hansman, G. S., Taylor, D. W., McLellan, J. S., Smith, T. J., Georgiev, I., Tame, J. R., ... & Katayama, K. (2012). Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle. Journal of Virology, JVI-06868.
Specifications
- Immunogen
- NV virus-like particles
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native NV VLP
- Species Reactivity
- NV
- Clone
- 5B18
- Applications
- ELISA, WB
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The VLP antibody has been reported in applications of ELISA, IF.
ELISA: Wells of 96-well microtiter plates (MaxiSorp; Nunc, Denmark) were each coated with 100 lof 100 ng of purified VLPs (in PBS, pH 7.3) and incubated overnight at 4°C.
Target
- Alternative Names
- VLP; virus-like particles
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-661 | Recombinant Mouse Anti-NV VLP Antibody Fab Fragment (5B18) | ELISA, WB | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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