Recombinant Mouse Anti-P. falciparum SUB1 Antibody (NIMP.M7) (CAT#: PABL-671)
Recombinant Mouse Antibody (NIMP.M7) is capable of binding to P. falciparum SUB1 , expressed in Chinese Hamster Ovary cells (CHO).
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Figure 1 Structure of the rPfSUB1cat–Prodp9–Fab complex and the NIMP.M7 epitope.
The mAb NIMP.M7 epitope is conserved in SUB1 orthologs as determined by western blot against rPfSUB1cat (lane 1).
Withers-Martinez, C., Strath, M., Hackett, F., Haire, L. F., Howell, S. A., Walker, P. A., ... & Blackman, M. J. (2014). The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. Nature communications, 5, 3726.
Figure 2 C1 and C2 do not affect expression, trafficking or maturation of PfSUB1.
IFA of mature wt 3D7 parasites following treatment for 6 h with DMSO only (1% v/v) or 2.5 µM C1, probed with the anti-PfSUB1 mAb NIMP.M7 or a rabbit anti-PfAMA1 serum.
Collins, C. R., Hackett, F., Strath, M., Penzo, M., Withers-Martinez, C., Baker, D. A., & Blackman, M. J. (2013). Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. PLoS pathogens, 9(5), e1003344.
Specifications
- Immunogen
- P. falciparum subtilisin-like protease 1
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native P. falciparum SUB1
- Species Reactivity
- P. falciparum
- Clone
- NIMP.M7
- Applications
- WB
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The PfSUB1 antibody has been reported in applications of WB, IF.
WB: Recombinant PfSUB1 (ref. 13) was used for western blot analysis at a dilution of 1:1,000. Purification of mAb NIMP.M7.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Antibody Products
ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-665 | Recombinant Mouse Anti-P. falciparum SUB1 Antibody Fab Fragment (NIMP.M7) | WB | Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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