Afuco™ Anti-Human TNFSF9 ADCC Recombinant Antibody (PF-05082566), ADCC Enhanced (CAT#: AFC-618CL)
Anti-TNFSF9 ADCC Enhanced Antibody (PF-05082566) is an ADCC enhanced antibody produced by our Afuco™ platform. PF-05082566 is a fully human IgG2 that binds to the extracellular domain of human 4-1BB with high affinity and specificity. In preclinical studies, this agonist antibody demonstrated its ability to activate NF-κB and induce downstream cytokine production, promote leukocyte proliferation, and inhibit tumor growth in a human PBMC xenograft tumor model. The mechanism of action and robust anti-tumor efficacy of PF-05082566 support its clinical development for the treatment of a broad spectrum of human malignancies.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59857/if_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59857/if_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125657-TNFSF9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125657-TNFSF9
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- FC, Activ, FuncS
- Related Disease
- Cancer
Product Property
- Purity
- 95% by HPLC
- Storage
- Store at -20°C. Open under aseptic conditions.
Applications
- Application Notes
- The antibody was validated for Flow Cytometry, Activation, Function Assay. For details, refer to Published Data.
Target
- Alternative Names
- CD137L; 4-1BB-L; TNFSF9; tumor necrosis factor (ligand) superfamily, member
- Gene ID
- 8744
- UniProt ID
- P41273
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1844z | Mouse Anti-TNFSF9 Recombinant Antibody (clone 15H10) | ELISA, WB | Mouse IgG1 |
| HPAB-0251-CN | Human Anti-TNFSF9 Recombinant Antibody (clone cSC113.57) | ELISA, FC | Chimeric (mouse/human) IgG1, κ |
| HPAB-0170-WJ | Mouse Anti-TNFSF9 Recombinant Antibody (clone SC1 13.153) | Block | Mouse IgG |
| FAMAB-1822CQ | Mouse Anti-TNFSF9 Recombinant Antibody (clone AT113-2) | Block, WB, FC | Mouse IgG2a |
| VS3-FY2902 | Mouse Anti-TNFSF9 Recombinant Antibody (VS3-FY2902) | IHC, ICC, FC, ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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