Anti-TnC-A1 Immunocytokine, scFv (F16)-IL2 (ACFP-SH028)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TnC-A1 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TnC-A1 as well as the biological activity of IL2. This fusion of cytokine to antibody fragment scFv allows for a targeted delivery and improves efficacy and pharmacokinetics. This immunocytokine was designed for treating solid tumors.
Specifications
- Target
- TnC-A1
- Molecule Class
- scFv-IL2
- Species Reactivity
- Human
- Host
- Human
- Expression Host
- CHO
- Clone
- F16
- Related Disease
- Solid tumors
- Cytokines 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- hunan
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TN; Hxb; Ten; TN-C; AI528729; cytotactin; tenascin-C; C130033P17Rik
- Entrez Gene ID
- 21923
- UniProt ID
- Q148T5
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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