Anti-TnC-A1 Antibody-Cytokine Fusion Protein, scFv (F16)-IL2 (CAT#: ACFP-SH029)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TnC-A1 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TnC-A1 as well as the biological activity of IL2. F16-IL2, a clinical-stage immunocytokine consisting of human interleukin (IL)-2 fused to the human antibody F16. No human anti-fusion protein antibodies (HAFA) response was detected. This immunocytokine was designed for treating metastatic breast cancer.
Specific Inquiry
Specifications
- Target
- TnC-A1
- Molecule Class
- scFv-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- F16
- Related Disease
- Metastatic breast cancer
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TN; Hxb; Ten; TN-C; AI528729; cytotactin; tenascin-C; C130033P17Rik
- Gene ID
- 21923
- UniProt ID
- Q148T5
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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