Anti-TnC-A1 Immunocytokine, scFv (F16)-IL2 (ACFP-SH029)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TnC-A1 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TnC-A1 as well as the biological activity of IL2. F16-IL2, a clinical-stage immunocytokine consisting of human interleukin (IL)-2 fused to the human antibody F16. No human anti-fusion protein antibodies (HAFA) response was detected. This immunocytokine was designed for treating metastatic breast cancer.
Specifications
- Target
- TnC-A1
- Molecule Class
- scFv-IL2
- Species Reactivity
- Human
- Host
- Human
- Expression Host
- CHO
- Clone
- F16
- Related Disease
- Metastatic breast cancer
- Cytokines 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- TN; Hxb; Ten; TN-C; AI528729; cytotactin; tenascin-C; C130033P17Rik
- Entrez Gene ID
- 21923
- UniProt ID
- Q148T5
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email: