Anti-Human CD40 Recombinant Antibody (Bleselumab)

Name: Anti-Human CD40 Recombinant Antibody (Bleselumab)
SKU: TAB-006ML
Rating: 5 (1 reviews)

CAT#: TAB-006ML

Recombinant monoclonal antibody to CD40. Bleselumab is a human monoclonal antibody that can be potentially used in the treatment of Lymphoma, B cell.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72868/156401_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31567/156626_A_6_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, Daudi, EFO-21)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000101017-CD40

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
IgG4, κ

Specificity
Human CD40

Species Reactivity
Human

Applications
ELISA, IHC, FC, IP, IF, Inhib, PK

Conjugate
Unconjugated

CAS
1453067-91-8

Generic Name
Bleselumab

UNII
AS3AZ5R46K

Related Disease
Lymphoma, B cell

Product Property

Purity
> 95% as determined by SDS-PAGE

Storage
Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

Application Notes
The CD40 antibody has been reported in applications of ELISA, IHC, FC, IP, IF, Inhib, PK.

Target

Alternative Names
Tumor necrosis factor receptor superfamily member 5; TNFRSF5; p50

Gene ID
958

UniProt ID
P25942

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Biosimilar Overview

Please refer to Bleselumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Bleselumab.

Related Diseases

Asthma

Systemic Lupus Erythematosus

Primary Immunodeficiency

Allograft Rejection

Autoimmune Thyroid Disease

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-006ML.pdf

MSDS

MSDS - TAB-006ML.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Bleselumab"

Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006ML)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD40. It is a human monoclonal antibody that can be potentially used in the treatment of Lymphoma, B cell.

See other products for "CD40"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-262	Anti-Human CD40 Recombinant Antibody (TAB-262)	IP, IF, FuncS, FC, Neut, ELISA, ICC	IgG1
TAB-188LC	Anti-Human CD40 Recombinant Antibody (chi220)	SPR, ELISA, Inhib, FuncS	Chimeric antibody (mouse/human)
TAB-202LC	Anti-CD40 Recombinant Antibody (TAB-202LC)	ELISA, FC, FuncS	Chimeric (mouse/rhesus) IgG1
TAB-203LC	Anti-CD40 Recombinant Antibody (TAB-203LC)	ELISA, FC, FuncS	Chimeric (mouse/rhesus) IgG4
TAB-188LC-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (chi220)	SPR, ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
AGTO-G079E	Anti-CD40 immunotoxin (scFv)-PE	Cytotoxicity assay, Function study

CAT	Product Name	Application
TAB-0061CL	Anti-Human CD40 Recombinant Antibody (PPAT-071-01)	ELISA, ADCC, CDC, FuncS
TAB-0062CL	Anti-Human CD40 Recombinant Antibody (PPAT-071-02)	ELISA, ADCC, CDC, FuncS
TAB-0063CL	Anti-Human CD40 Recombinant Antibody (PPAT-071-03)	ELISA, ADCC, CDC, FuncS
TAB-0064CL	Anti-Human CD40 Recombinant Antibody (PPAT-071-04)	ELISA, ADCC, CDC, FuncS
TAB-0065CL	Anti-Human CD40 Recombinant Antibody (PPAT-071-05)	ELISA, ADCC, CDC, FuncS

CAT	Product Name	Application	Type
TAB-189LC-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (F4)	SPR, ELISA	Humanized antibody
TAB-190LC-S(P)	Anti-Human CD40 Recombinant Antibody scFv Fragment (L3.17)	SPR, ELISA	Humanized antibody
TAB-194LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-194LC-S(P))	ELISA	Humanized scFv
TAB-200LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-200LC-S(P))	ELISA	Human scFv
TAB-204LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-204LC-S(P))	SPR, ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-195LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-195LC-S(P))	ELISA	Human scFv
TAB-196LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-196LC-S(P))	ELISA	Human scFv
TAB-197LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-197LC-S(P))	ELISA	Human scFv
TAB-198LC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (TAB-198LC-S(P))	ELISA	Human scFv
TAB-470CQ	Anti-Human CD40 Recombinant Antibody (Selicrelumab)	ELISA, IHC, FC, IP, IF, FuncS	IgG2, κ

CAT	Product Name	Application	Type
NEUT-362CQ	Human Anti-CD40 Recombinant Antibody (clone 5D12)	Block, ELISA, FC, SPR, IP, IHC	Human IgG4, κ
NEUT-363CQ	Mouse Anti-CD40 Recombinant Antibody (clone 5C3)	FC, Block, Activ	Mouse IgG1, κ
NEUT-366CQ	Rat Anti-CD40 Recombinant Antibody (clone MAB0819)	Block, Activ	Rat IgG2

CAT	Product Name	Application	Type
NEUT-364CQ	Mouse Anti-CD40 Recombinant Antibody (clone CBL829)	WB, Neut	Mouse IgG2b, κ
NEUT-367CQ	Mouse Anti-CD40 Recombinant Antibody (clone CBL013)	WB, IHC, Neut	Mouse IgG2

CAT	Product Name	Application	Type
NEUT-365CQ	Hamster Anti-CD40 Recombinant Antibody (clone HM40-3)	FC, Block, Costim, IHC	Hamster IgM

CAT	Product Name	Application	Type
MOR-4059	Hi-Affi™ Rabbit Anti-CD40 Recombinant Antibody (clone SI126DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOB-105LC	Human Anti-CD40 Recombinant Antibody (MOB-105LC)	FC, FuncS	Human IgG1, κ
MOB-106LC	Human Anti-CD40 Recombinant Antibody (MOB-106LC)	FC, FuncS, ELISA	Human IgG2, κ
MOB-107LC	Human Anti-CD40 Recombinant Antibody (MOB-107LC)	FC, FuncS, ELISA	Human IgG2, κ
VS-0724-XY18	Mouse Anti-CD40 Agonistic Antibody (VS-0724-XY18)	FC, Agonistic assays, CyTOF®, ICC	Mouse IgG2b
VS-0724-XY19	Rat Anti-Cd40 Agonistic Antibody (VS-0724-XY19)	FC, IP, Agonistic assays, CyTOF®	Rat IgG2a

CAT	Product Name	Application	Type
HPAB-0162-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0162-YC)	FC	Human IgG
HPAB-0163-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0163-YC)	FC	Human IgG
HPAB-0164-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0164-YC)	FC, Agonist	Human IgG
HPAB-0165-YC	Human Anti-CD40 Recombinant Antibody (HPAB-0165-YC)	FC	Human IgG
HPAB-0166-YC	Human Anti-CD40 Recombinant Antibody (clone S2C6)	FC, FuncS	Human IgG

CAT	Product Name	Application	Type
NS-021CN	Human Anti-CD40 Recombinant Antibody (NS-021CN)	ELISA, IF, Block, FuncS	Human IgG
NS-021CN-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (NS-021CN-F(E))	ELISA	Human Fab
NS-021CN-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (NS-021CN-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-0138CQ-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0138CQ-F(E))	ELISA, FC, IHC, Block	Human Fab
HPAB-0139CQ-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0139CQ-F(E))	ELISA, FC, IHC, IP, Block	Human Fab
HPAB-0118-YJ-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-0118-YJ-F(E))	FuncS	Human Fab
HPAB-M0479-YC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-M0479-YC-F(E))	ELISA, FC, FuncS	Human Fab
HPAB-M0480-YC-F(E)	Human Anti-CD40 Recombinant Antibody; Fab Fragment (HPAB-M0480-YC-F(E))	ELISA, FC, FuncS	Human Fab

CAT	Product Name	Application	Type
HPAB-M0479-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0479-YC-S(P))	ELISA, FC, FuncS	Human scFv
HPAB-M0480-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0480-YC-S(P))	ELISA, FC, FuncS	Human scFv
HPAB-M0481-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0481-YC-S(P))	ELISA, FC	Human scFv
HPAB-M0482-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0482-YC-S(P))	ELISA, FC	Human scFv
HPAB-M0483-YC-S(P)	Human Anti-CD40 Recombinant Antibody; scFv Fragment (HPAB-M0483-YC-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-152	Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-152)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-262	Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-262)	IP, IF, FuncS, FC, Neut, ELISA	ADCC enhanced antibody
AFC-TAB-759	Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-759)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody
AFC-TAB-470CQ	Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-470CQ)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-006ML	Afuco™ Anti-CD40 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006ML)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-1218WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1218WJ)	ELISA	Llama VHH
HPAB-1219WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1219WJ)	ELISA	Llama VHH
HPAB-1220WJ	Recombinant Llama Anti-CD40 Single Domain Antibody (HPAB-1220WJ)	ELISA	Llama VHH

CAT	Product Name	Application	Type
VS-0724-YC1328	AbPlus™ Anti-CD40 Magnetic Beads (VS-0724-YC1328)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0924-YC117	Mouse Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC117), CDC Enhanced	ELISA, ADCC, CDC	Antibody hexamer
VS-0924-YC118	Human Anti-CD40 Recombinant Antibody Hexamer (VS-0924-YC118), CDC Enhanced	ELISA, Block, FC, IF, Activ, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-0225-XY52	CytoStream™ Armenian Hamster Anti-CD40 Recombinant Antibody (clone HM40-3)	FC, Block	Armenian Hamster IgM, kappa

CAT	Product Name	Application	Type
VS-0325-FY89	Rat Anti-CD40 (clone FGK45) scFv-Fc Chimera	FC, WB, Agonist	Rat IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC514	Recombinant Anti-CD40 Vesicular Antibody, EV Displayed (VS-0425-YC514)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1181	Anti-CD40 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC30	Recombinant Anti-CD40 (CRD1 x ECD) Biparatopic Antibody, Tandem scFv	ELISA, FC, Neut, IHC, IP, IF	Tandem scFv
VS-0525-YC206	Recombinant Anti-CD40 (CRD2 x CRD1) Biparatopic Antibody, Tandem scFv	ELISA, FC, IF, IHC, IP	Tandem scFv
VS-0525-YC208	Recombinant Anti-CD40 Biparatopic Antibody, Tandem scFv (Bleselumab x Selicrelumab)	ELISA, FC, IP, IF, IHC	Tandem scFv

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