Gemtuzumab ozogamicin
CAT#: TP-107CL
Recombinant humanized IgG4, kappa antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin, isolated from fermentation of a bacterium, Micromonospora echinospora ssp. calichensis. The antibody portion of Mylotarg binds specifically to the CD33 antigen, The anti-CD33 hP67.6 antibody is produced by mammalian cell suspension culture using a myeloma NS0 cell line. Gemtuzumab ozogamicin (trade name Mylotarg) was withdrawn in 2010 when a clinical trial showed the drug increased patient death and exhibited no advantages over traditional cancer therapies.
Specifications
- Type
- Biotech
- Trade name
- Mylotarg
- UNII
- 8GZG754X6M
Target
- Function
- Humanized anti-CD33 IgG4k mAb conjugated to calicheamicin, a small-molecule chemotherapeutic agent
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Highly effective
Our lab used Gemtuzumab Ozogamicin for in vitro cytotoxicity assays on AML cell lines. The product was highly effective, and we observed consistent results across various experimental setups. Highly recommend for research!
Clear instructions
Storing Gemtuzumab Ozogamicin was straightforward with clear instructions. However, remember not to agitate the solution too much during handling. It's sensitive but immensely powerful for targeted research.
Great product for research
A great product for those researching CD33+ malignancies. Be sure to handle with care and follow all storage recommendations. The cytotoxic effects are profound and very specific to the target cells.
Q&As
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What safety measures should be followed when handling Gemtuzumab Ozogamicin in a laboratory setting?
A: Because of its cytotoxic nature, lab coats and gloves are among the PPE that researchers should wear. To prevent inhalation or skin contact, work in a biological safety cabinet and properly dispose of any trash.
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For reconstituting Gemtuzumab Ozogamicin for experimental tests, what is the recommended diluent?
A: Sterile, preservative-free saline (0.9% sodium chloride) is recommended for reconstituting Gemtuzumab Ozogamicin. Ensure that the diluent is at room temperature before reconstitution to avoid cold shock.
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What should be done if Gemtuzumab Ozogamicin has been accidentally frozen and thawed?
A: Freezing may compromise the efficacy and stability of Gemtuzumab Ozogamicin. It is advisable to discard any product if it has been accidentally frozen to ensure experimental integrity.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TP-107CL, RRID: AB_3112057)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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