PDZ domain anti-K+ channels (SPD-L173)

The PDZ domain that bound K+ channels was isolated from the library using Yeast Two-hybrid techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities for K+ channels as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Scaffold Name
PDZ domain
PSD-95 protein
Core Structure
K+ channels
Expression Host
E. coli
ELISA; IHC; Microscopy; FC; WB; FuncS
Alternative Names
PSD-95 protein; PDZ domain; K+ channels; potassium channels

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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