PE-A*69:01/Human BRCC3 (DAYRRIHSL) MHC Tetramer (CAT#: MHC-LC4432)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human BRCC3 of peptide DAYRRIHSL covering 245-253 and A*69:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48737/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48737/if_selected.jpg
Figure 2 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185515-BRCC3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185515-BRCC3
Specifications
- Allele
- A*69:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- BRCC3
- Antigen Species
- Human
- Peptide
- DAYRRIHSL
- Range
- 245-253
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
- Alternative Names
- BRCC3; BRCA1/BRCA2-containing complex subunit 3; C6.1A; BRCC36; CXorf53
- Gene ID
- 79184
- UniProt ID
- P46736
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1483MZ | Mouse Anti-BRCC3 Recombinant Antibody (clone BU4C2) | ELISA, IHC-P, WB | Mouse IgG1 |
| VS3-FY1669 | Rabbit Anti-BRCC3 Recombinant Antibody (clone R01-7E5) | WB, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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