Specifications

Immunogen
Synthetic peptide of human BRCC36

Host Species
Rabbit

Type
Rabbit IgG

Specificity
Human, Mouse and Rat BRCC3

Species Reactivity
Human, Mouse, Rat

Clone
R01-7E5

Applications
Western Blot, Immunoprecipitation

MW
The calculated weight of the target protein is approximately 36 kDa, while the observed molecular weight stands at 36 kDa.

Related Disease
Moyamoya Disease 4 With Short Stature, Hypergonadotropic Hypogonadism, And Facial Dysmorphism and Hereditary Breast Ovarian Cancer Syndrome

Product Property

Purification
Affinity Purified

Format
Liquid

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
BRCA1/BRCA2-Containing Complex Subunit 3; BRCA1/BRCA2-Containing Complex Subunit 36; BRCA1-A Complex Subunit BRCC36; BRISC Complex Subunit BRCC36; CXorf53; BRCC36; C6.1A

Gene ID
79184

UniProt ID
P46736

Sequence Similarities
Belongs to the peptidase M67A family. BRCC36 subfamily.

Cellular Localization
Cytoplasm, Cytoskeleton, Nucleus

Post Translation Modifications
Acetylation
Phosphoprotein

Protein Refseq
XP_005274808.1; XP_054183838.1; NP_001018065.1; NP_001229569.1; NP_077308.1

Function
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains.
Does not have activity toward 'Lys-48'-linked polyubiquitin chains.
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).

Recommended Products

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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CAT	Product Name	Application	Type
MOB-1483MZ	Mouse Anti-BRCC3 Recombinant Antibody (clone BU4C2)	ELISA, IHC-P, WB	Mouse IgG1

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