PE-B*07:02/Human KPNA2 (ELPIVTPAL) MHC Tetramer
CAT#: MHC-LC4437
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human KPNA2 of peptide ELPIVTPAL covering 306-314 and B*07:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41270/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/945_C8_3_selected.jpg
Normal Tissue
Figure 3 Testis
Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_4_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_8_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_B_7_5.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15460/34903_A_8_4.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182481-KPNA2
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Specifications
- Allele
- B*07:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- KPNA2
- Antigen Species
- Human
- Peptide
- ELPIVTPAL
- Range
- 306-314
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- Alternative Names
- KPNA2; Importin subunit alpha-2; QIP2; RCH1; IPOA1; SRP1alpha; SRP1-alpha
- Gene ID
- 3838
- UniProt ID
- P52292
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|---|---|---|---|
| MOB-3100z | Mouse Anti-KPNA2 Recombinant Antibody (clone 4B8) | WB, ELISA, FC, ICC, IF, IHC, ICC, IF | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0276MZ | Chicken Anti-Importin α2 subunit Polyclonal IgY | WB | Chicken antibody |
| BRD-1037MZ | Chicken Anti-KPNA2 Polyclonal IgY | WB | Chicken antibody |
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| CAT | Product Name | Application | Type |
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| MOR-1972 | Hi-Affi™ Recombinant Rabbit Anti-KPNA2 Monoclonal Antibody (DS1972AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1202 | Anti-KPNA2 Immunohistochemistry Kit | IHC | |
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