PE-DRB1*01:01/Human NCKAP1L (AILEFRAMAQFSRKTD) MHC Tetramer

Name: PE-DRB1*01:01/Human NCKAP1L (AILEFRAMAQFSRKTD) MHC Tetramer
SKU: MHC-LC3345
Rating: 5 (1 reviews)

CAT#: MHC-LC3345

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human NCKAP1L of peptide AILEFRAMAQFSRKTD and DRB1*01:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line NB-4

Immunofluorescent staining of human cell line NB-4 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39490/1714_D9_3_selected.jpg

Normal Tissue Figure 2 IHC staining of human hippocampus

Immunohistochemical staining of human hippocampus shows strong cytoplasmic and nuclear positivity in neuronal cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40772/ihc_selected.jpg

Normal Tissue Figure 3 Lymph node

Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39490/108612_A_7_8.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39490/108612_B_9_5.jpg

Normal Tissue Figure 5 Stomach

Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39490/108612_A_4_1.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39490/108612_A_8_5.jpg

Normal Tissue Figure 7 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity:>75%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39490/108612_A_6_6.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (HL-60, HMC-1, NB-4, REH, THP-1, U-937)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123338-NCKAP1L

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Specifications

Allele
DRB1*01:01

Class
Class II

MHC Species
Human

Antigen
NCKAP1L

Antigen Species
Human

Peptide
AILEFRAMAQFSRKTD

Conjugate
PE

Application
FCM

Target

Antigen Introduction
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.

Alternative Names
NCKAP1L; Nck-associated protein 1-like; HEM1

Gene ID
3071

UniProt ID
P55160

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Datasheet

Datasheet - MHC-LC3345.pdf

MSDS

MSDS - MHC-LC3345.pdf

COA

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