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NCKAP1L
Loading...Anti-NCKAP1L Products
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- Class: Class II
- Antigen: NCKAP1L
- Antigen Species: Human
- Peptide: AILEFRAMAQFSRKTD
- Conjugate: PE
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- Anti-NCKAP1L Immunohistochemistry Kit (VS-0325-XY1462)
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- Species Reactivity: Human, Mouse, Rat
- Target: NCKAP1L
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.
Protein class
Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Kupffer cells, monocytes, Hofbauer cells, NK-cells, Macrophages, dendritic cells, B-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HL-60, HMC-1, NB-4, REH, THP-1, U-937)
Interaction
In hematopoietic cells, component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1L/HEM1 and WASF2/WAVE2 (PubMed:16417406, PubMed:32647003). Interacts with ARHGAP4, PIK3C3/VPS34 and PPP1R12A/MYPT1 (PubMed:16417406). Interacts with mammalian target of rapamycin complex 2 (mTORC2) components, including MTOR and RICTOR (PubMed:32647003).
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