A*02:01/Human BCR-ABL (GVRGRVEEI) MHC Monomer
CAT#: MHC-YF298
This product is a MHC monomer of biotinylated peptide/MHC complex composed BCR-ABL-derived peptide of GVRGRVEEI sequence and A*02:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- BCR-ABL
- Antigen Species
- Human
- Peptide
- GVRGRVEEI
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
- Alternative Names
- ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase; ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl
- Gene ID
- 25
- UniProt ID
- P00520
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