A*02:01/Human L-dopachrome tautomerase (YAIDLPVSV) MHC Pentamer (CAT#: MHC-YF515)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed L-dopachrome tautomerase-derived peptide of YAIDLPVSV sequence covering 488-496 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10742/1844_A3_33_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10742/1844_A3_33_selected.jpg
Figure 2 Skin 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10743/ihc_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10743/ihc_selected.jpg
Figure 3 Skin
(Melanocytes Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10743/26206_B_9_1.jpg
(Melanocytes Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10743/26206_B_9_1.jpg
Figure 4 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000080166-DCT
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000080166-DCT
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- L-dopachrome tautomerase
- Antigen Species
- Human
- Peptide
- YAIDLPVSV
- Range
- 488-496
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases associated with DCT include Microphthalmia and Hermansky-Pudlak Syndrome 3. Among its related pathways are Phenylalanine metabolism and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.
- Alternative Names
- Dopachrome Tautomerase; L-Dopachrome Delta-Isomerase; Dopachrome Delta-Isomerase; Tyrosine-Related Protein 2; L-Dopachrome Isomerase; EC 5.3.3.12; TYRP2; TRP-2;
- Gene ID
- 1638
- UniProt ID
- P40126
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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