Human Anti-A. fumigatus mitF Recombinant Antibody (clone 17A5) (CAT#: FAMAB-1848CQ)

Figure 1 Asp f 1–induced anaphylaxis in human FcεRIα–transgenic mice.

Human FcεRIα-transgenic mice were sensitized with human Asp f 1-specific IgE mAbs 17A5 and 14H4 or saline. Animals were challenged with 5 μg of recombinant Asp f 1 or the maximum tolerated dose of extract manufactured by GREER, HS, ALKB, or AlrgyL. Each group had 3 mice. Error bars represent the SEM, with temperature differences between control and allergen-challenged animals assessed by paired 2-tailed t test with a calculated P value of less than 0.05 deemed significant and highlighted by an asterisk. rAsp f 1, recombinant Asp f 1.

Wurth, M. A., Hadadianpour, A., Horvath, D. J., Daniel, J., Bogdan, O., Goleniewska, K., ... & Smith, S. A. (2018). Human IgE mAbs define variability in commercial Aspergillus extract allergen composition. JCI insight, 3(20).