Human Anti-ADGRL3 Recombinant Antibody (clone LK30)
CAT#: VS-0724-FY27
This is a human antibody that binds to ADGRL3. Clone LK30 binds to the Lec domain of ADGRL3 with an affinity of 7 nM. LK30 binds to full-length ADGRL3 and ADGRL1 expressed on cell surface expressed receptors with high affinity of 131 nM and 147 nM, respectively. SRE signaling assays show that LK30 acts as an agonist of ADGRL3.
Published Data
ELISA
Figure 1. Recombinant Human Anti-ADGRL3 Antibody (LK30) in ELISA.
Representative single-point protein ELISA of the antibody binders obtained from phage display. Epitope mapping shows that sABs LK29-31 bind to the lectin domain of both ADGRL3 and ADGRL1.
1. Kordon, Szymon P., et al. "Isoform-and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder." Nature Communications 14.1 (2023): 635. 2. under Open Access license cc BY 4.0. without modification.
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human ADGRL3
- Species Reactivity
- Human
- Clone
- LK30
- Applications
- Agonist, ELISA, Flow Cytometry, Western Blot
- Related Disease
- Idiopathic Cd4-Positive T-Lymphocytopenia and Epiglottis Cancer
Product Property
- Clonality
- Monoclonal Antibody
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Adhesion G Protein-Coupled Receptor L3; Calcium-Independent Alpha-Latrotoxin Receptor 3; Latrophilin-3; CIRL-3; LPHN3; LEC3; Latrophilin Homolog 3 (Cow)
- Gene ID
- 23284
- UniProt ID
- Q9HAR2
- Long Name
- Adhesion G Protein-Coupled Receptor L3
- Sequence Similarities
- Belongs to the G-protein coupled receptor 2 family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
Cell projection, axon
Cell junction
- Post Translation Modifications
- Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit
O-glycosylated (major) and N-glycosylated
Glycosylation at Asn93, Ser410, Ser423, Asn464, Asn549, Asn746, Asn759, Asn804, Asn830, and Asn1076
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 14 sites, 4 O-linked glycans (6 sites)
- Protein Refseq
- XP_011530093.1; XP_016863418.1; XP_016863419.1; XP_016863420.1; XP_016863422.1
- Function
- Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells.
Plays a role in the development of glutamatergic synapses in the cortex.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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