Anti-ATAD2 (clone W24V214) Recombinant Antibody Coupled Liposome (VS-1024-FY211) (CAT#: VS-1024-FY211)

• Potential Clinical Applications
• Ovarian cancer

• Clone
• W24V214

• Antibody Type
• IgG1

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that has been meticulously engineered to specifically bind to and target the ATAD2 protein. ATAD2, an ATPase family member, plays a crucial role in various cellular processes, including gene regulation and chromatin remodeling. By selectively recognizing this particular protein, the engineered antibody is designed to inhibit its function or facilitate its detection, making it a valuable tool in both research and potential therapeutic applications.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• ATAD2

• Introduction
• A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.

• Alternative Names
• ATPase Family, AAA Domain Containing 2; AAA Nuclear Coregulator Cancer-Associated Protein; ANCCA; EC 3.6.1.3; PRO2000; CT137

• Full Name
• ATPase Family, AAA Domain Containing 2

• Gene ID
• 29028

• UniProt ID
• Q6PL18

• Sequence Similarities
• Belongs to the AAA ATPase family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Ubiquitination at Lys311, Lys175, Lys489, Lys931, and Lys1042 (NX_Q6PL18 [NX_Q6PL18-1])
  Modification sites at PhosphoSitePlus (Q6PL18)
  Glycosylation from GlyGen (Q6PL18) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_011515296.1; XP_011515297.1; XP_011515298.1; XP_047277678.1; XP_047277679.1

• Function
• May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1.
  May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters.
  May be required for histone hyperacetylation.

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