Anti-ATAD2 (clone W24V214) Recombinant Antibody Coupled Liposome (VS-1024-FY211)
CAT#: VS-1024-FY211
Anti-ATAD2 antibody-conjugated liposomes have shown significant potential in ovarian cancer research by effectively targeting tumor cells. Through this specific binding, the liposomes enable precise drug delivery, enhancing therapeutic efficacy while reducing side effects. Additionally, ATAD2 is a tumor marker whose expression is closely related to the progression of ovarian cancer, which gives this strategy greater applied value. Future clinical studies will further validate its effectiveness and safety in the treatment of ovarian cancer.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29424/602_G5_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29424/583_G5_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29424/598_G5_1_red_green.jpg
Normal Tissue
Figure 4 Esophagus
Squamous epithelial cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56158/121376_B_6_1.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56158/121376_A_9_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56158/121376_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Pachytene spermatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Preleptotene spermatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56158/121376_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56158/121376_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156802-ATAD2
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More Infomation
Specifications
- Potential Clinical Applications
- Ovarian cancer
Product Composition
- Clone
- W24V214
- Antibody Type
- IgG1
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that has been meticulously engineered to specifically bind to and target the ATAD2 protein. ATAD2, an ATPase family member, plays a crucial role in various cellular processes, including gene regulation and chromatin remodeling. By selectively recognizing this particular protein, the engineered antibody is designed to inhibit its function or facilitate its detection, making it a valuable tool in both research and potential therapeutic applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ATAD2
- Introduction
- A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.
- Alternative Names
- ATPase Family, AAA Domain Containing 2; AAA Nuclear Coregulator Cancer-Associated Protein; ANCCA; EC 3.6.1.3; PRO2000; CT137
- Full Name
- ATPase Family, AAA Domain Containing 2
- Gene ID
- 29028
- UniProt ID
- Q6PL18
- Sequence Similarities
- Belongs to the AAA ATPase family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Ubiquitination at Lys311, Lys175, Lys489, Lys931, and Lys1042 (NX_Q6PL18 [NX_Q6PL18-1])
Modification sites at PhosphoSitePlus (Q6PL18)
Glycosylation from GlyGen (Q6PL18) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011515296.1; XP_011515297.1; XP_011515298.1; XP_047277678.1; XP_047277679.1
- Function
- May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1.
May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters.
May be required for histone hyperacetylation.
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Datasheet
MSDS
COA
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|---|---|---|---|
| DrMAB-224 | Human Anti-ATAD2 Recombinant Antibody (clone D372) | ELISA, IP-MS | Human IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0272 | Hi-Affi™ Rabbit Anti-ATAD2 Recombinant Antibody (clone DS272AB) | WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC72 | CytoStream™ Rabbit Anti-ATAD2 Recombinant Antibody (VS13-YC72) | WB, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY571 | Anti-ATAD2 Immunohistochemistry Kit | IHC |
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