Recombinant Anti-CCL21 Eliminating Antibody, pH-Sensitive (MOR06935_g3-23_g3j var.)
CAT#: VS-0625-YC47
The anti-CCL21 eliminating antibody is an engineered pH-sensitive antibody against human and cynomolgus CCL21. CCL21 plays roles in lymphocyte homing and immune system modulation. The antibody has a novel CCL21-sweeping activity in vivo, which selectively eliminatesthe soluble CCL21 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51210/140347_A_8_8_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51210/140347_B_9_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51210/140347_A_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51210/140347_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (Daudi, K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137077-CCL21
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human and Cynomolgus CCL21
- Species Reactivity
- Human, Cynomolgus
- Clone
- MOR06935_g3-23_g3j var.
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CCL21; chemokine (C-C motif) ligand 21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21; C-C motif chemokine 21; beta chemokine exodus-2; secondary lymphoid tissue chemokine; Efficient Chemoattractant for Lymphocytes; small inducible cytokine subfamily A (Cys-Cys), member 21
- Gene ID
- 6366
- UniProt ID
- O00585
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0625-YC47. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CCL21"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1495CL | Anti-Human CCL21 Recombinant Antibody (MOR06935_g3-23_g3j (also known as QBP359)) | FuncS | Fully human antibody |
| TAB-1495CL-S(P) | Anti-Human CCL21 Recombinant Antibody scFv Fragment (MOR06935_g3-23_g3j (also known as QBP359)) | FuncS | Fully human antibody |
| TAB-1495CL-F(E) | Anti-Human CCL21 Recombinant Antibody Fab Fragment (MOR06935_g3-23_g3j (also known as QBP359)) | FuncS | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0358CT | Mouse Anti-CCL21 Recombinant Antibody (clone NN0257-3I37) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0505 | Hi-Affi™ Rabbit Anti-CCL21 Recombinant Antibody (clone DS505AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1059 | Anti-CCL21 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
-2-1.png)
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, WB, BLI, SPR
-5.jpg)
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, IHC, FC, IP, IF, FuncS
-4.jpg)
Application: FC, FuncS, IA, IF, IP, IHC
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
Application: ELISA, Activ, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
