Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (BMS-936559)-IL15/IL15Rα

Name: Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (BMS-936559)-IL15/IL15Rα
SKU: VS-0624-FY101
Rating: 5 (1 reviews)

CAT#: VS-0624-FY101

BMS-936559 is a high-affinity, fully humanized, PD-L1-specific monoclonal antibody that inhibits the binding of PD-L1 to PD-1 and CD80. Long-acting forms of the cytokine interleukin (IL)-15 and fusion protein complexes consisting of a mutant form of IL-15, in which asparagine at amino acid 72 (N72D) is replaced by aspartic acid (IL-15N72D), complexed with the soluble IL-15 receptor alpha (IL-15 Ralpha; IL-15Ra) Fc domain (IL-15Ra-sFc) (IL-15N72D/IL-15Ra-sFc), have potential antitumor activity.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg

Normal Tissue Figure 5 Placenta

Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274

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Specifications

Target
CD274

Molecule Class
IgG-IL15/IL15Rα

Species Reactivity
Human

Clone
BMS-936559

Related Disease
Cancer

Cytokine 1
IL15/IL15Rα

Cytokines 1 Description
Interleukin (IL)-15-N72D superagonist-complexed with IL-15RαSushi-Fc fusion protein has been reported to exhibit significant anti-tumor activity in murine myeloma, rat bladder cancer, and murine glioblastoma models.

Cytokine 1 Species
Human

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
CD274 (CD274 molecule) is a protein-coding gene. Diseases associated with CD274 include combined lymphoma and tracheal carcinoma. Its associated pathways include ALK signaling and phosphorylation of CD3 and TCR zeta chain. An important homolog of this gene is PDCD1LG2.

Alternative Names
CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1

Gene ID
29126

UniProt ID
Q9NZQ7

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Datasheet

Datasheet - VS-0624-FY101.pdf

MSDS

MSDS - VS-0624-FY101.pdf

COA

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CAT	Product Name	Application	Type
TAB-0992CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0992CL)	Inhib, FC, SPR	Mouse IgG
TAB-0262CL-F(E)	Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0262CL-F(E))	ELISA, WB, SPR, FuncS	Mouse Fab
TAB-1009CL-F(E)	Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1009CL-F(E))	WB, IHC	Mouse Fab
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CAT	Product Name	Application	Type
TAB-0995CL	Human Anti-CD274 Recombinant Antibody (TAB-0995CL)	ELISA, FC	Chimeric (Mouse/Human) IgG1, κ
TAB-0995CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P))	ELISA, FC	Human scFv
TAB-0995CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E))	ELISA, FC	Chimeric (Mouse/Human) Fab

CAT	Product Name	Application	Type
TAB-0263CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0263CL-F(E))	ELISA, WB, SPR, FuncS	Humanized Fab
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TAB-0265CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0265CL-F(E))	ELISA, WB, SPR, FuncS	Humanized Fab
TAB-0266CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0266CL-F(E))	ELISA, WB, SPR, FuncS	Humanized Fab
TAB-0267CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0267CL-F(E))	ELISA, WB, SPR, FuncS	Humanized Fab

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TAB-1003CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1003CL-F(E))	FC, ELISA	Human Fab
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TAB-1005CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1005CL-F(E))	FC	Human Fab
TAB-1006CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-1006CL-F(E))	FC	Human Fab
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MOR-0548	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB)	ELISA	Rabbit IgG
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CAT	Product Name	Application	Type
HPAB-0400LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0400LY)	ELISA, RIA, WB	Human IgG1
HPAB-0401LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0401LY)	ELISA, RIA, WB	Human IgG1
HPAB-0402LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0402LY)	ELISA, RIA, WB	Human IgG1
HPAB-0403LY	Human Anti-PDCD1 Recombinant Antibody (HPAB-0403LY)	ELISA, RIA, WB	Human IgG1
HPAB-0404LY	Human Anti-CD274 Recombinant Antibody (HPAB-0404LY)	ELISA, RIA, WB	Human IgG1

CAT	Product Name	Application	Type
HPAB-0406LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0406LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0407LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0407LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0408LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0408LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0409LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0409LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0410LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0410LY-S(P))	ELISA, RIA, WB	Human scfv

CAT	Product Name	Application	Type
HPAB-0400LY-F(E)	Human Anti-PDCD1 Recombinant Antibody; Fab Fragment (HPAB-0400LY-F(E))	ELISA, RIA, WB	Human Fab
HPAB-0401LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0401LY-F(E))	ELISA, RIA, WB	Human Fab
HPAB-0402LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0402LY-F(E))	ELISA, RIA, WB	Human Fab
HPAB-0403LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0403LY-F(E))	ELISA, RIA, WB	Human Fab
HPAB-0404LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0404LY-F(E))	ELISA, RIA, WB	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-417CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody
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VS-0924-YC110	Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC	Antibody hexamer
VS-0924-YC111	Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC, Inhib	Antibody hexamer

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VS-1024-XY375	Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0225-XY32	CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0325-FY65	Human Anti-CD274 (clone MI4736) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC608	Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608)	Block, ELISA, FC, Cell-uptake

CAT	Product Name	Application
VS-0525-XY1152	Anti-CD274 Immunohistochemistry Kit	IHC
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VS-0525-XY1154	Anti-Human CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC202	Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv	ELISA, IHC, FC, IP, IF	Tandem scFv

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