Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (BMS-936559)-IL7

Name: Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (BMS-936559)-IL7
SKU: VS-0624-FY102
Rating: 5 (1 reviews)

CAT#: VS-0624-FY102

BMS-936559 is a fully human monoclonal antibody that binds to PD-L1 on pancreatic tumor cells, preventing it from binding to the receptor PD-1, thereby creating an anti-tumor immune environment in vitro. This is a fusion molecule in which a PD-L1 inhibitor is fused to a human IL-7 protein or a fragment thereof via a peptide linker. The fusion molecule may exhibits a synergistic anti-tumor effect for research.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg

Normal Tissue Figure 5 Placenta

Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274

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Specifications

Target
CD274

Molecule Class
IgG-IL7

Species Reactivity
Human

Clone
BMS-936559

Related Disease
Cancer

Cytokine 1
IL7

Cytokines 1 Description
IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but not by normal lymphocytes.

Cytokine 1 Species
Human

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
CD274 (CD274 molecule) is a protein-coding gene. Diseases associated with CD274 include combined lymphoma and tracheal carcinoma. Its associated pathways include ALK signaling and phosphorylation of CD3 and TCR zeta chain. An important homolog of this gene is PDCD1LG2.

Alternative Names
CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1

Gene ID
29126

UniProt ID
Q9NZQ7

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Datasheet

Datasheet - VS-0624-FY102.pdf

MSDS

MSDS - VS-0624-FY102.pdf

COA

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HPAB-N0307-YC-VHH	Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0307-YC-VHH)	ELISA, FC, BL	Humanized VHH
NBD-0065-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH)	ELISA	Camelid VHH
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CAT	Product Name	Application	Type
TAB-0190CL	Anti-Human CD274 Recombinant Antibody (PD1-AB1)	FC, ELISA, FuncS
TAB-0998CL	Anti-Human CD274 Recombinant Antibody (BII61-62)	ELISA, FuncS	Human antibody
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TAB-1000CL	Human Anti-CD274 Recombinant Antibody (TAB-1000CL)	Inhib, FC	Human IgG1
TAB-1001CL	Human Anti-CD274 Recombinant Antibody (TAB-1001CL)	ADCC, Block, FuncS	Human IgG

CAT	Product Name	Application	Type
TAB-0262CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0262CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Mouse IgG
TAB-0992CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0992CL-S(P))	FC	Mouse scFv
TAB-0993CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0993CL-S(P))	FC	Mouse scFv
TAB-0994CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0994CL-S(P))	ELISA, FC	Mouse scFv
TAB-1009CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-1009CL-S(P))	WB, IHC	Mouse scFv

CAT	Product Name	Application	Type
TAB-0263CL	Human Anti-CD274 Recombinant Antibody (TAB-0263CL)	ELISA, WB, SPR, FuncS	Humanized IgG
TAB-0264CL	Human Anti-CD274 Recombinant Antibody (TAB-0264CL)	ELISA, WB, SPR, ADCC, CDC, FuncS, Inhib	Humanized IgG
TAB-0265CL	Human Anti-CD274 Recombinant Antibody (TAB-0265CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG
TAB-0266CL	Human Anti-CD274 Recombinant Antibody (TAB-0266CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG
TAB-0267CL	Human Anti-CD274 Recombinant Antibody (TAB-0267CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-0995CL	Human Anti-CD274 Recombinant Antibody (TAB-0995CL)	ELISA, FC	Chimeric (Mouse/Human) IgG1, κ
TAB-0995CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P))	ELISA, FC	Human scFv
TAB-0995CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E))	ELISA, FC	Chimeric (Mouse/Human) Fab

CAT	Product Name	Application	Type
NEUT-324CQ	Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6)	IHC-P, FC, Neut, ICC	Mouse IgG2b, κ
NEUT-325CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-206)	Neut	Human IgG1, κ
NEUT-326CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-207)	ELISA, Neut	Human IgG1, κ
NEUT-327CQ	Mouse Anti-CD274 Recombinant Antibody (clone MIH1)	FC, FuncS, Neut, IHC, IF	Mouse IgG1, κ
NEUT-330CQ	Rat Anti-CD274 Recombinant Antibody (clone MIH5)	FC, FuncS, Neut, IHC-Fr, WB	Rat IgG2a, λ

CAT	Product Name	Application	Type
NEUT-328CQ	Rat Anti-CD274 Recombinant Antibody (VMC171)	Block, FC	Rat IgG2
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NEUT-331CQ	Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1)	ELISA, Block	Mouse IgG1, λ
NEUT-332CQ	Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009)	Block	Rabbit IgG

CAT	Product Name	Application	Type
MOR-0548	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB)	ELISA	Rabbit IgG
MOR-4049	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS)	ELISA	Rabbit IgG
MOR-4050	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS)	ICC, IF, FC	Rabbit IgG
MOR-4051	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0193-YC	Human Anti-CD274 Recombinant Antibody (HPAB-0193-YC)	ELISA	Humanized IgG4, κ
HPAB-0194-YC	Mouse Anti-CD274 Recombinant Antibody (HPAB-0194-YC)	ELISA	Mouse IgG
HPAB-0195-YC	Human Anti-CD274 Recombinant Antibody (HPAB-0195-YC)	SPR	Humanized IgG
HPAB-0236-FY	Human Anti-CD274 Recombinant Antibody (HPAB-0236-FY)	WB, IHC, IP, ELISA, FC	Human IgG
HPAB-0237-FY	Human Anti-CD274 Recombinant Antibody (HPAB-0237-FY)	ELISA, FC	Human IgG

CAT	Product Name	Application	Type
HPAB-0933LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0933LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0934LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0934LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0935LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0935LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0936LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0936LY-F(E))	Inhib, ELISA	Human Fab
HPAB-0937LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0937LY-F(E))	Inhib, ELISA	Human Fab

CAT	Product Name	Application	Type
HPAB-0406LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0406LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0407LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0407LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0408LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0408LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0409LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0409LY-S(P))	ELISA, RIA, WB	Human scfv
HPAB-0410LY-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0410LY-S(P))	ELISA, RIA, WB	Human scfv

CAT	Product Name	Application	Type
AFC-TAB-417CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody
AFC-TAB-418CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ)	ELISA, IHC, FC, IP, IF, BL	ADCC enhanced antibody

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VS-0924-YC110	Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC	Antibody hexamer
VS-0924-YC111	Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC, Inhib	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY375	Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0225-XY32	CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0325-FY65	Human Anti-CD274 (clone MI4736) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC608	Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608)	Block, ELISA, FC, Cell-uptake

CAT	Product Name	Application
VS-0525-XY1152	Anti-CD274 Immunohistochemistry Kit	IHC
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VS-0525-XY1154	Anti-Human CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC202	Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv	ELISA, IHC, FC, IP, IF	Tandem scFv

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