Human Anti-CD274 Recombinant Antibody (clone MPDL3280A) (CAT#: HPAB-M0361-YC)
Provided is a new anti-human PDL1 antibody and can be used in medicine and biology.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
PK
Figure 1 Mean (± SD) serum concentration-time profiles following a single IV administration of 0.5, 5, and 20 mg·kg−1 MPDL3280A to cynomolgus monkeys.
N = 4 animals per group. The minimum quantifiable concentration (MQC) in the MPDL3280A concentration ELISA was 0.075 μg·mL−1. Values below MQC were interpreted as missing for summary statistics.
Deng, R., Bumbaca, D., Pastuskovas, C. V., Boswell, C. A., West, D., Cowan, K. J., ... & Koeppen, H. (2016, April). Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. In MAbs (Vol. 8, No. 3, pp. 593-603). Taylor & Francis.
IHC
Figure 2 PD-L1 prevalence and response rates in patients with UBC.
Representative images (320 magnification) of PD-L1 IHC staining of tumours from patients with UBC. c, Response rates, including overall response, stable disease and progressive disease by tumour-infiltrating immune cell PD-L1 IHC status. Includes both confirmed
and unconfirmed responses per RECIST v1.1. Five of seventeen responses were unconfirmed. Best response is not known for seven patients.
Powles, T., Eder, J. P., Fine, G. D., Braiteh, F. S., Loriot, Y., Cruz, C., ... & Shen, X. (2014). MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature, 515(7528), 558-562.
FuncS
Figure 3 Antitumour activity of MPDL3280A by immunohistochemistry (IHC) tumour-infiltrating immune cell (IC) and biomarker status.
Kaplan-Meier curve showing the phase I percentage of progression-free survival by patient IHC (IC) status. Censored data are indicated by vertical tick marks. CI, confidence interval; NSCLC, non-small cell lung cancer; ORR, objective response rate; PD, progressive disease; PFS, progression free survival; PR, partial response; RECIST, Response Evaluation Criteria in Solid Tumours; SD, stable disease.
Herbst, R. S., Soria, J. C., Kowanetz, M., Fine, G. D., Hamid, O., Gordon, M. S., ... & Kohrt, H. E. (2014). Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature, 515(7528), 563-567.
Specifications
- Host Species
- Human
- Type
- Human IgG4, κ
- Specificity
- Human CD274
- Species Reactivity
- Human
- Clone
- MPDL3280A
- Applications
- PK, IHC, FuncS, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CD274 antibody has been reported in applications of Pharmacokinetic, Immunohistochemistry, Functional Assay, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1;
- Gene ID
- 29126
- UniProt ID
- Q9NZQ7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone MPDL3280A"
See other products for "Cd274"
Select a product category from the dropdown menu below to view related products.
Please select product type
Single Domain Antibody Products
IgG Antibody Products
Fab Antibody Products
Chimeric Antibody Products
Mouse Antibody Products
Humanized Antibody Products
Human Antibody Products
Neutralizing Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
ScFv Antibody Products
ADCC Enhanced Antibody Products
Hexamer Antibody Products
Non-Human Primate (NHP) Antibody Products
Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
ScFv-Fc Chimera Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-305-sdAb | Recombinant Anti-Mouse Cd274 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| HPAB-N0408-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0408-YC-VHH) | ELISA, FC, BL | Human VHH |
| HPAB-N0307-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0307-YC-VHH) | ELISA, FC, BL | Humanized VHH |
| NBD-0065-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH) | ELISA | Camelid VHH |
| NBD-0066-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH) | ELISA, Inihb | Camelid VHH |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-M0361-YC. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
-1-1.png)
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA
Application: ELISA, FC, WB, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Inhib
Application: ELISA, FC
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
