Rabbit Anti-CD274 Recombinant Antibody (VS-0624-FY67) (CAT#: VS-0624-FY67)

• Immunogen
• A portion of amino acids 39-191 from the human protein was used as the immunogen for this PD-L1 antibody.

• Host Species
• Rabbit

• Specificity
• Human CD274

• Related Disease
• Cancer

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• Programmed cell death 1; PD-L1; PD-L1

• Long Name
• Programmed death-ligand 1

• Sequence Similarities
• Belongs to the immunoglobulin superfamily. BTN/MOG family.

• Cellular Localization
• Cell membrane, Endosome, Membrane, Nucleus, Secreted

• Post Translation Modifications
• Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation (PubMed:28813410).
  Ubiquitinated by MARCHF8; leading to degradation (PubMed:34183449).
  Glycosylation at Asn35, Asn192, Asn200, and Asn219 (NX_Q9NZQ7 [NX_Q9NZQ7-1])
  Modification sites at PhosphoSitePlus (Q9NZQ7)
  Glycosylation from GlyGen (Q9NZQ7) 5 sites

• Protein Refseq
• XP_047279218.1; XP_054218785.1; NP_001254635.1; NP_001300958.1; NP_054862.1

• Function
• Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410).
  As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response.

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